An inhibitor of α-glucosidases (IC50s = 0.35

Miglitol – 100 mg

Brand:
Cayman
CAS:
72432-03-2
Storage:
-20
UN-No:
Non-Hazardous - /

Miglitol is an inhibitor of α-glucosidases (IC50s = 0.35, 0.11, 1.3, and 1.2 μM for human lysosomal α-glucosidase and rat sucrase, maltase, and isomaltase, respectively).{22626} It is selective for human α- over β-glucosidase (IC50 = 84 μM). Miglitol (10 mg/kg) decreases blood glucose levels in sucrose-loaded Goto-Kakizaki (GK) type 2 diabetic rats.{49506} Dietary administration of miglitol (40 mg/100 g diet) for 8 weeks decreases changes in HbA1c levels compared with control rats fed a normal diet. Formulations containing miglitol have been used in the treatment of type 2 diabetes.  

 

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Description

An inhibitor of α-glucosidases (IC50s = 0.35, 0.11, 1.3, and 1.2 μM for human lysosomal α-glucosidase and rat sucrase, maltase, and isomaltase, respectively); selective for α- over β-glucosidase (IC50 = 84 μM); decreases blood glucose levels in sucrose-loaded GK type 2 diabetic rats at 10 mg/kg; dietary administration decreases changes in HbA1c levels compared with control rats fed a normal diet 40 mg/100 g diet

Formal name: 1-(2-hydroxyethyl)-2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol

Synonyms:  BAY-1099|Diastabol|Glyset|Seibule

Molecular weight: 207.2

CAS: 72432-03-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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