A 6α-methyl derivative of prednisolone

Methylprednisolone – 1 g

Brand:
Cayman
CAS:
83-43-2
Storage:
-20
UN-No:
Non-Hazardous - /

Prednisolone is the active metabolite of the synthetic corticosteroid prednisone, which is used to suppress inflammation and autoimmunity, as well as in other conditions.{19136} Methylprednisolone is a 6α-methyl derivative of prednisolone, a variation which reduces its binding to corticosteroid-binding globulin and increases penetration into target tissues.{19136} It alters gene expression, like prednisolone, through both the glucocorticoid and mineralocorticoid receptors.{22687}  

 

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Description

A 6α-methyl derivative of prednisolone, a variation which reduces its binding to corticosteroid-binding globulin and increases penetration into target tissues; alters gene expression through both the glucocorticoid and mineralocorticoid receptors

Formal name: 11β,17,21-trihydroxy-6α-methyl-pregna-1,4-diene-3,20-dione

Synonyms:  Medesone|Medrol|Noretona|NSC 19987|U 7532

Molecular weight: 374.5

CAS: 83-43-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Immunosuppressants

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