A phenylpiperidine derivative that potently and selectively inhibits the reuptake of serotonin

Paroxetine (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
78246-49-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Paroxetine is a phenylpiperidine derivative that potently and selectively inhibits the reuptake of serotonin, blocking the human serotonin transporter with a Ki value of 0.72 nM.{24255} It less effectively blocks the human norepinephrine and dopamine transporters (Ki = 440 and 1,900 nM, respectively).{24255} Paroxetine also inhibits, at concentrations in excess of 1 µM, nitric oxide synthase activity in the cytosol of hamster brain.{5162} Selective serotonin uptake inhibitors, including paroxetine, are used in cases of depression and anxiety disorder.{23626,23628}  

 

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Description

A phenylpiperidine derivative that potently and selectively inhibits the reuptake of serotonin, blocking the hSERT with a Ki value of 0.72 nM; less effectively blocks the human norepinephrine and dopamine transporters (Ki = 440 and 1900 nM, respectively)

Formal name: (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine, monohydrochloride

Synonyms:  BRL 29060A

Molecular weight: 365.8

CAS: 78246-49-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Nitric Oxide Synthases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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