Blocks cortisol synthesis by inhibiting steroid 11β-hydroxylase in adrenal cortex (IC50 = 7.8 μM); also binds with high affinity to CYP450 in hepatic microsomes and induces rat hepatic CYP1A1 and CYP3A gene expression

Metyrapone – 1 g

Brand:
Cayman
CAS:
54-36-4
Storage:
-20
UN-No:
Non-Hazardous - /

Metyrapone blocks cortisol synthesis by inhibiting steroid 11β-hydroxylase in adrenal cortex (IC50 = 7.8 μM).{24101} Metyrapone binds with high affinity to cytochrome P(CYP)450 in hepatic microsomes and induces rat hepatic CYP1A1 and CYP3A gene expression.{24100,24099} It is used to assess adrenal insufficiency, to address hypercortisolism characteristic of Cushing’s syndrome, and may be of clinical value in the treatment of depression and in reducing brain damage resulting from hypoxia-ischemia.{24098,24096,24097}  

 

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Description

Blocks cortisol synthesis by inhibiting steroid 11β-hydroxylase in adrenal cortex (IC50 = 7.8 μM); also binds with high affinity to CYP450 in hepatic microsomes and induces rat hepatic CYP1A1 and CYP3A gene expression

Formal name: 2-methyl-1,2-di-3-pyridinyl-1-propanone

Synonyms:  NSC 25265|SU 4885

Molecular weight: 226.3

CAS: 54-36-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids

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