An inhibitor of Ca2+ mobilization

TAS 301 – 1 mg

Brand:
Cayman
CAS:
193620-69-8
Storage:
-20
UN-No:
Non-Hazardous - /

TAS 301 (10 μM) impedes Ca2+ mobilization and Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) activation that inhibits vascular smooth muscle cell (VSMC) proliferation in vitro.{34683,34682} At a concentration of 10 μM, TAS 301 also inhibits platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of focal adhesion kinase and paxillin and promotes cytoskeletal rearrangment.{34683} TAS 301 (3-100 mg/kg) inhibits migration and proliferation of VSMCs and prevents arterial intimal thickening in vivo in a model of balloon-injured arteries in rats.{34680} In a micro pig model, TAS 301 administration (30-100 mg/kg) prevents coronary artery stenosis after balloon overstretch injury.{34681}  

 

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Description

An inhibitor of Ca2+ mobilization, CaM kinase II activation (10 μM); inhibits PKC signaling, phosphorylation of focal adhesion kinase and paxillin (10 μM); inhibits VSMC migration and proliferation and arterial intimal thickening in vivo (3-100 mg/kg in rats)

Formal name: 3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one

Synonyms: 

Molecular weight: 357.4

CAS: 193620-69-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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