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Concanavalin A – 100 mg

Brand:
Cayman
CAS:
11028-71-0
Storage:
-20
UN-No:
Non-Hazardous - /

Concanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis.{23899} Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures.{23897,8536} At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells.{23900,23898} Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.{23899,23901}  

 

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Description

A plant lectin that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis; widely used in affinity chromatography purifications of various glycoproteins and cellular structures; also used to induce liver injury in experimental mouse models of autoimmune hepatitis

Formal name:

Synonyms: 

Molecular weight: 0

CAS: 11028-71-0

Purity:

Formulation: A lyophilized powder

Product Type|Biochemicals|Natural Products||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity

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