A potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM); binds directly with the pathway activator Smo (Ki = 44 nM); blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin

CUR 61414 – 5 mg

Brand:
Cayman
CAS:
334998-36-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

CUR 61414 is a potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM).{24330,24331} It binds directly with the pathway activator Smoothened (Ki = 44 nM).{20488} CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.{24330,24332}  

 

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Description

A potent inhibitor of hedgehog-induced cellular activity (IC50 = 100-200 nM); binds directly with the pathway activator Smo (Ki = 44 nM); blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin

Formal name: N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-butanamide

Synonyms:  G-856

Molecular weight: 550.7

CAS: 334998-36-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Hedgehog Signaling||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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