An inhibitor of the dopachrome tautomerase activity of MIF in vitro (IC50 = 7 µM) and in cells (IC50 = 25 µM); blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis

MIF Antagonist – 1 mg

Brand:
Cayman
CAS:
478336-92-4
Storage:
-20
UN-No:
Non-Hazardous - /

Macrophage migration inhibitory factor (MIF) is a regulator of inflammation that also has roles in cancer and autoimmune diseases.{24242} MIF exhibits both tautomerase and oxidoreductase activities, although how these are linked to MIF’s physiological and pathophysiological actions is unclear.{24242} MIF antagonist, also known as ISO-1, is an inhibitor of the dopachrome tautomerase activity of MIF in vitro (IC50 = 7 µM) and in cells (IC50 = 25 µM).{24243,24246} It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis.{24246} MIF antagonist also demonstrates protective effects in airway and gastrointestinal inflammation in mice.{24244,24245}  

 

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Description

An inhibitor of the dopachrome tautomerase activity of MIF in vitro (IC50 = 7 µM) and in cells (IC50 = 25 µM); blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis

Formal name: 4,5-dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid, methyl ester

Synonyms:  ISO-1|Macrophage Migration Inhibitory Factor

Molecular weight: 235.2

CAS: 478336-92-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Gastric Disease||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock

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