An inhibitor of MCT1 and MCT2 (Kis = 2.3 and Xenopus oocytes expressing human receptors); selective for MCT1 and MCT2 over MCT4 (Ki = >10 μM); inhibits L-lactate uptake in and proliferation of murine 4T1 breast cancer cells (IC50s = 25 and 20.2 nM

AR-C 155858 – 1 mg

Brand:
Cayman
CAS:
496791-37-8
Storage:
-20
UN-No:
Non-Hazardous - /

AR-C 155858 is an inhibitor of monocarboxylate transporter 1 (MCT1) and MCT2 (Kis = 2.3 and Xenopus oocytes expressing the human receptors).{48632} It is selective for MCT1 and MCT2 over MCT4 (Ki = >10 μM). AR-C 155858 inhibits L-lactate uptake in and proliferation of murine 4T1 breast cancer cells (IC50s = 25 and 20.2 nM, respectively).{48633}  

 

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Description

An inhibitor of MCT1 and MCT2 (Kis = 2.3 and Xenopus oocytes expressing human receptors); selective for MCT1 and MCT2 over MCT4 (Ki = >10 μM); inhibits L-lactate uptake in and proliferation of murine 4T1 breast cancer cells (IC50s = 25 and 20.2 nM, respectively)

Formal name: 6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Synonyms: 

Molecular weight: 461.5

CAS: 496791-37-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Metabolism

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