An organic disulfide that inhibits TGM2 with an IC50 value of approximately 2.5 mM; neuroprotective in mouse models of Huntington’s disease; also inhibits caspase 3

Cystamine (hydrochloride) – 500 g

Brand:
Cayman
CAS:
56-17-7
Storage:
-20
UN-No:
Non-Hazardous - /

Tissue transglutaminase (TGM2) post-translationally modifies proteins by catalyzing intermolecular cross-linkages between glutamine and lysine side chains.{30036} TGM2 has roles in neurodegenerative disorders, celiac sprue, cancer, and fibrotic diseases.{30036,30033} Cystamine is an organic disulfide that inhibits TGM2 with an IC50 value of approximately 2.5 mM.{30037} It is orally available and is neuroprotective in mouse models of Huntington’s disease.{30034,30032} Cystamine also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.{30035}  

 

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Description

An organic disulfide that inhibits TGM2 with an IC50 value of approximately 2.5 mM; neuroprotective in mouse models of Huntington’s disease; also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease

Formal name: 2,2′-dithiobis-ethanamine, dihydrochloride

Synonyms: 

Molecular weight: 225.2

CAS: 56-17-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease

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