A small molecule inhibitor of Bcl-2 proteins (IC50 = ~ 9 µM) that induces apoptosis of human acute myeloid leukemia (HL-60) cells (50 µM induces 90% loss of viability)

HA-14-1 – 5 mg

Brand:
Cayman
CAS:
927635-64-1
Storage:
-20
UN-No:
Non-Hazardous - /

HA-14-1 is a small molecule that binds the surface pocket of Bcl-2 proteins (IC50 = ~ 9 µM) and induces apoptosis by interfering with its interaction with the Bak peptide and activating Apaf-1 and caspase-9 and -3.{25684} It can also bind to the antiapoptotic Bcl-2 proteins Bcl-xl and Bcl-W.{25683} HA-14-1 has been shown to induce apoptosis of human acute myeloid leukemia (HL-60) cells (50 µM induces 90% loss of viability).{25684}  

 

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Description

A small molecule inhibitor of Bcl-2 proteins (IC50 = ~ 9 µM) that induces apoptosis of human acute myeloid leukemia (HL-60) cells (50 µM induces 90% loss of viability)

Formal name: (αR,4R)-rel-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid, ethyl ester

Synonyms: 

Molecular weight: 409.2

CAS: 927635-64-1

Purity: ≥95% (mixture of isomers)

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis

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