A potent

Akt Inhibitor VIII – 1 mg

Brand:
Cayman
CAS:
612847-09-3
Storage:
-20
UN-No:
Non-Hazardous - /

Akt inhibitor VIII is a potent allosteric inhibitor of Akt1 and Akt2 (IC50s = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC50 = 2.2 µM).{24205,24204,24208} It is a poor or ineffective inhibitor of a wide range of other serine-threonine kinases.{24203} Akt inhibitor VIII is cell permeable, blocking insulin regulation of forkhead box 01 activity at 1 µM in rat hepatoma cells.{24203}  

 

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Description

A potent, allosteric inhibitor of Akt1 and Akt2 (IC50 = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC50 = 2.2 µM); cell permeable, blocking insulin regulation of FOXO1 activity at 1 µM in rat hepatoma cells

Formal name: 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one

Synonyms: 

Molecular weight: 551.7

CAS: 612847-09-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKB/Akt||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling

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