An antagonist of VEGFR1

Vatalanib (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
212141-51-0
Storage:
-20
UN-No:
Non-Hazardous - /

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively.{24346,24345} It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases.{24346,24344,24345} Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.{18281,24343}  

 

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Description

An antagonist of VEGFR1, VEGFR2, and VEGFR3 with IC50 values of 77, 37, and 190 nM, respectively; less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on additional kinases; completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice

Formal name: N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, dihydrochloride

Synonyms:  CGP 79787|PTK/ZK|PTK787

Molecular weight: 419.7

CAS: 212141-51-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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