A cell permeable phenoxazine derivative that suppresses IGF-1-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM; inhibits the growth of Rh1

Akt Inhibitor X – 1 mg

Brand:
Cayman
CAS:
925681-41-0
Storage:
-20
UN-No:
Non-Hazardous - /

Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM.{23567} This compound has been shown to block IGF-1-stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 μM.{23567} Inhibition of Akt phosphorylation by 5 μM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.{23567}  

 

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Description

A cell permeable phenoxazine derivative that suppresses IGF-1-stimulated phosphorylation of Akt with an IC50 value of 1-2 μM; inhibits the growth of Rh1, Rh18, and Rh30 cells with IC50 values of 2-5 μM

Formal name: 2-chloro-N,N-diethyl-10H-phenoxazine-10-butanamine, monohydrochloride

Synonyms:  10-DEBC

Molecular weight: 381.3

CAS: 925681-41-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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