A potent

SU11274 – 1 mg

Brand:
Cayman
CAS:
658084-23-2
Storage:
-20
UN-No:
Non-Hazardous - /

MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.{23657} Dysregulation of c-Met occurs in many types of cancer.{23657} SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM).{23656} It has much less or no activity against other receptor tyrosine kinases.{23656} SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.{23656,23655}  

 

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Description

A potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM); induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines

Formal name: (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide

Synonyms:  Met Kinase Inhibitor

Molecular weight: 568.1

CAS: 658084-23-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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