An anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM)

Mitoxantrone (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
70476-82-3
Storage:
-20
UN-No:
Non-Hazardous - /

Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation.{23708,23705} It also inhibits HIV-1 integrase (IC50 = 3.8 μM).{23704} Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1.{23706} Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.{23702,23707,23703}  

 

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Description

An anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation; human HIV-1 integrase (IC50 = 3.8 μM); exported from cells in an ATP- and glutathione-dependent manner by MRP1

Formal name: 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione, dihydrochloride

Synonyms:  NCI 301739|NSC 301739

Molecular weight: 517.4

CAS: 70476-82-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|DNA Damage and Repair|DNA Intercalating Agents||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Neuroscience

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