An L-type calcium channel blocker; inhibits calcium influx in cardiac and vascular smooth muscle; inhibits calcium-induced contractions in depolarized rat aorta (IC50 = 1.9 nM)

Amlodipine – 5 g

Brand:
Cayman
CAS:
88150-42-9
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.{23674} Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues. Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition in vitro and in vivo.{23673} Formulations containing amlodipine have been used in the treatment of hypertension.  

 

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Description

An L-type calcium channel blocker; inhibits calcium influx in cardiac and vascular smooth muscle; inhibits calcium-induced contractions in depolarized rat aorta (IC50 = 1.9 nM), displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues,

Formal name: 3-ethyl 5-methyl ester 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid

Synonyms:  Intervask|Pelmec

Molecular weight: 408.9

CAS: 88150-42-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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