A fluoroquinolone antibiotic; active against 390 clinical isolates of various bacteria (MIC90s = ≤0.25 µg/ml)

Moxifloxacin (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
186826-86-8
Storage:
-20
UN-No:
Non-Hazardous - /

Moxifloxacin is a fluoroquinolone antibiotic.{53219} It is active against 390 clinical isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria (MIC90s = ≤0.25 µg/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 µg/ml, respectively).{53219,53220} Moxifloxacin is an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays).{53221} It prevents S. aureus- or P. aeruginosa-induced increases in bronchoalveolar lavage fluid (BALF) neutrophil infiltration and reduces S. aureus- or P. aeruginosa-induced increases in lung chemokine (C-X-C motif) ligand 1 (CXCL1) and IL-1β levels in mouse models of bacterial pneumonia when administered at a dose of 100 mg/kg twice per day for two days.{53222} Moxifloxacin (100 mg/kg) decreases the number of lung and spleen colony forming units (CFUs) in a mouse model of systemic M. tuberculosis infection.{53223} Formulations containing moxifloxacin have been used in the treatment of various bacterial infections.  

 

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A fluoroquinolone antibiotic; active against 390 clinical isolates of various bacteria (MIC90s = ≤0.25 µg/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 µg/ml, respectively); an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays); prevents S. aureus- and P. aeruginosa-induced increases in BALF neutrophil infiltration and reduces S. aureus- and P. aeruginosa-induced increases in lung CXCL1 and IL-1β levels in mouse models of bacterial pneumonia at 100 mg/kg twice per day for two days; decreases the number of lung and spleen CFUs in a mouse model of systemic M. tuberculosis infection at 100 mg/kg

Formal name: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid, monohydrochloride

Synonyms:  BAY 12-8039

Molecular weight: 437.9

CAS: 186826-86-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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