JWH 019 (Item No. 13633) is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB1) (Ki = 9.8 nM) and the peripheral cannabinoid (CB2) (Ki = 5.6 nM) receptors.{16797} JWH 019 N-(5-hydroxyhexyl) metabolite is an expected urinary metabolite of JWH 019 that should be detectable both in serum and urine based on studies of the metabolism of the structurally similar compound, JWH 018.{18617,18291,19353,16797} The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.
A urinary metabolite of JWH 019, detectable both in serum and urine
Formal name: [1-(5-hydroxyhexyl)-1H-indol-3-yl]-1-naphthalenyl-methanone
Synonyms:
Molecular weight: 371.5
CAS: 1435934-47-6
Purity: ≥98%
Formulation: A crystalline solid
Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Drugs of Abuse||Research Area|Forensic Chemistry & Toxicology|Cannabinoids|Synthetic Cannabinoids
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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