An irreversible inhibitor of IκBα phosphorylation

BAY 11-7085 – 5 mg

Brand:
Cayman
CAS:
196309-76-9
Storage:
-20
UN-No:
Non-Hazardous - /

In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import.{19822} BAY 11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM).{16037} It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation.{16037,24580,24840} BAY 11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.{24581}  

 

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Description

An irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM); blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation

Formal name: 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2E-propenenitrile

Synonyms: 

Molecular weight: 249.3

CAS: 196309-76-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation

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