The more predominant-occurring (~80%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol

25(R)-27-hydroxy Cholesterol – 1 mg

Brand:
Cayman
CAS:
20380-11-4
Storage:
-20
UN-No:
Non-Hazardous - /

The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(R)-27-hydroxy Cholesterol is the more predominant-occurring (~80%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}  

 

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Description

The more predominant-occurring (~80%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol

Formal name: (25R)-cholest-5-ene-3β,26-diol

Synonyms:  (25R)-26-hydroxy Cholesterol

Molecular weight: 402.7

CAS: 20380-11-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs||Research Area|Lipid Biochemistry|Sterol Lipids

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