A nucleoside analog and HIV-1 reverse transcriptase inhibitor (Ki = 2.1 µM for the wild-type enzyme); inhibits replication of a variety of HIV-1 and HIV-2 strains

Abacavir (sulfate) – 50 mg

Brand:
Cayman
CAS:
216699-07-9
Storage:
-20
UN-No:
Non-Hazardous - /

Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 µM for the wild-type enzyme).{18404} It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3′-azido-3′-deoxythymidine (zidovudine; Item No. 15492) or 2′,3′-dideoxyinosine (didanosine; Item No. 23715), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 µM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection.  

 

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Description

A nucleoside analog and HIV-1 reverse transcriptase inhibitor (Ki = 2.1 µM for the wild-type enzyme); inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to zidovudine or didanosine in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM); inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes (mean IC50 = 0.26 µM); inhibits HBV DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of FIV in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively)

Formal name: (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol, monosulfate

Synonyms: 

Molecular weight: 384.4

CAS: 216699-07-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Nucleoside Reverse Transcriptase Inhibitors (NRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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