A cysmethynil analog that inhibits Icmt with an IC50 value of 0.86 μM; demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC50s = 2.63 vs. 27.4 μM

CAY10677 – 1 mg

Brand:
Cayman
CAS:
1443253-20-0
Storage:
-20
UN-No:
Non-Hazardous - /

Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Isoprenylcysteine carboxyl methyltransferase (Icmt) catalyzes the methylation of C-terminal prenylcysteine residues, the last step in this process. CAY10677 is an analog of the Icmt inhibitor cysmethynil (Item No. 14745) that was developed for improved solubility and cell permeability.{23335} CAY10677 inhibits Icmt with an IC50 value of 0.86 μM and demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC50s = 2.63 versus 27.4 μM, respectively) and human prostate cancer PC3 cells (IC50s = 2.55 versus 25.2 μM, respectively).{23335}  

 

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Description

A cysmethynil analog that inhibits Icmt with an IC50 value of 0.86 μM; demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC50s = 2.63 vs. 27.4 μM, respectively) and human prostate cancer PC3 cells (IC50s = 2.55 vs. 25.2 μM, respectively)

Formal name: 5-(2-amino-5-pyrimidinyl)-N,N-diethyl-1-octyl-1H-indole-3-methanamine

Synonyms:  Icmt Inhibitor 15

Molecular weight: 407.6

CAS: 1443253-20-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Cancer

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