A broad spectrum inhibitor of MMPs

Batimastat – 5 mg

Brand:
Cayman
CAS:
130370-60-4
Storage:
-20
UN-No:
Non-Hazardous - /

Batimastat is a broad spectrum inhibitor of matrix metalloproteinases (MMP), with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14.{25118,25119,25120,25121} It also potently inhibits TNFα-converting enzyme (IC50 = 14.9 nM).{25119} Because of its action on MMPs, batimastat has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer.{25117} Batimastat less effectively inhibits the processing of the low affinity IgE receptor CD23 (IC50 = 100 nM).{25122}  

 

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Description

A broad spectrum inhibitor of MMPs, with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14; also potently inhibits TACE (IC50 = 14.9 nM); has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer

Formal name: (2R,3S)-N4-hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-butanediamide

Synonyms:  BB-94

Molecular weight: 477.6

CAS: 130370-60-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Migration & Metastasis

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