A selective phosphatase inhibitor which prevents dephosphorylation of eIF2α

Salubrinal – 5 mg

Brand:
Cayman
CAS:
405060-95-9
Storage:
-20
UN-No:
Non-Hazardous - /

Salubrinal is a selective phosphatase inhibitor that prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α), protecting PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM).{24280,24278} It appears to block the action of protein phosphatase 1 (PP1) on eIF2α although it does not mimic calyculin A, another PP1-selective inhibitor, in toxicity or phosphorylation pattern.{24280} Salubrinal also prevents replication of herpes virus (IC50 = 3 μM), by inhibiting dephosphorylation of eIF2α.{24280} As eIF2α has a role in bone formation, salubrinal is being studied for its effects in osteoporosis.{24279}  

 

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Description

A selective phosphatase inhibitor which prevents dephosphorylation of eIF2α, protecting cells from ER stress-mediated apoptosis (EC50 = 15 μM); prevents replication of herpes virus (IC50 = 3 μM) and alters bone formation

Formal name: (2E)-3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide

Synonyms: 

Molecular weight: 479.8

CAS: 405060-95-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Infectious Disease|Viral Diseases|HSV

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