A lipophilic electrophile that has profound effects on oxidative and immunological pathways; activates the transcription factor Nrf2

Dimethyl fumarate – 250 g

Brand:
Cayman
CAS:
624-49-7
Storage:
-20
UN-No:
Non-Hazardous - /

Dimethyl fumarate is a lipophilic electrophile that has profound effects on oxidative and immunological pathways.{23442} It rapidly interacts in a Michael addition reaction with glutathione or is metabolized to monomethyl fumarate.{23442} Dimethyl fumarate at low micromolar levels activates the nuclear factor erythroid 2-related factor 2 (Nrf2), resulting in an antioxidant response featuring heme oxygenase-1 expression and increased glutathione levels.{23442} It also suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis.{23440,23439} Through these actions dimethyl fumarate alters the course of psoriasis and may reduce inflammation related to multiple sclerosis.{23440,23441}  

 

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Description

A lipophilic electrophile that has profound effects on oxidative and immunological pathways; activates the transcription factor Nrf2, resulting in heme oxygenase-1 expression and increased glutathione levels; suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis

Formal name: 2E-butenedioic acid, 1,4-dimethyl ester

Synonyms:  trans-Butenedioic Acid dimethyl ester|NSC 167432|NSC 25942

Molecular weight: 144.1

CAS: 624-49-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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