A peptide antagonist of PAR2 which blocks activation by trypsin (IC50 = ~50 μM) but not by the synthetic agonist SLIGRL-NH2; does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein; used to study PAR2 action in cells and in animals

FSLLRY-amide – 1 mg

Brand:
Cayman
CAS:
245329-02-6
Storage:
-20
UN-No:
Non-Hazardous - /

FSLLRY-amide is a peptide antagonist of protease-activated receptor (PAR) 2 which blocks activation by trypsin (IC50 = ~50 μM) but not by the synthetic agonist SLIGRL-NH2 (Item No. 16723).{23427} It does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein.{23427} It can be used to study PAR2 action in cells and in animals.{23416,23415}  

 

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Description

A peptide antagonist of PAR2 which blocks activation by trypsin (IC50 = ~50 μM) but not by the synthetic agonist SLIGRL-NH2; does not affect thrombin-induced activation of PAR1 or trypsin-mediated proteolysis of casein; used to study PAR2 action in cells and in animals

Formal name: L-phenylalanyl-L-seryl-L-leucyl-L-leucyl-L-arginyl-L-tyrosinamide

Synonyms: 

Molecular weight: 797

CAS: 245329-02-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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