A selective

GSK3β Inhibitor VIII – 5 mg

Brand:
Cayman
CAS:
487021-52-3
Storage:
-20
UN-No:
Non-Hazardous - /

GSK3β Inhibitor VIII is an ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3β (Ki = 38 nM; IC50 = 104 nM).{24857} It does not significantly inhibit the closely related cyclin-dependent kinase (Cdk)2 or Cdk5 (Kis = > 100 μM).{24857} GSK3β Inhibitor VIII demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC50 = 2.7 μM) at a GSK3-specific site (Ser396) in cells stably expressing human four-repeat tau protein and also by protecting β-amyloid-exposed N2A neuroblastoma cells against cell death.{24857}  

 

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Description

A selective, ATP-competitive inhibitor of the serine/threonine kinase, glycogen synthase kinase 3β (Ki = 38 nM; IC50 = 104 nM); demonstrates neuroprotective effects by inhibiting tau phosphorylation (IC50 = 2.7 μM) at a GSK3-specific site (Ser396) in cells stably expressing human four-repeat tau protein and also by protecting β-amyloid-exposed N2A neuroblastoma cells against cell death

Formal name: N-[(4-methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)-urea

Synonyms:  AR 0133418|AR 014418|Glycogen Synthase Kinase 3β Inhibitor VIII|SN 4521

Molecular weight: 308.3

CAS: 487021-52-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|GSK3||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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