A potent and selective antagonist of the group II metabotropic glutamate receptors mGluR2 and mGluR3 (IC50s = 21 and 14 nM

LY341495 – 50 mg

Brand:
Cayman
CAS:
201943-63-7
Storage:
-20
UN-No:
Non-Hazardous - /

LY341495 is a potent and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively, for human isoforms).{24137,24136,24138} It less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 μM, respectively).{24136} In rat forebrain tissue, LY341495 may bind mGluR3 more avidly than mGluR2.{24135} LY341495 can be effectively used in isolated cells, tissues, and in vivo.{24135,24134,24133} In mice, it penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.{24134,21982,21984}  

 

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Description

A potent and selective antagonist of the group II metabotropic glutamate receptors mGluR2 and mGluR3 (IC50s = 21 and 14 nM, respectively); less effectively blocks mGluR8 and mGluR7 (IC50s = 173 and 990 nM, respectively) can be effectively used in isolated cells, tissues, and in vivo

Formal name: αS-amino-α-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid

Synonyms: 

Molecular weight: 353.4

CAS: 201943-63-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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