A potent agonist of the serotonin 4 receptor (5-HT4

Tegaserod (maleate) – 10 mg

Brand:
Cayman
CAS:
189188-57-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Tegaserod (maleate) is a potent agonist of the serotonin 4 receptor (5-HT4, Ki = 3.9-31 nM).{24432,24434} As 5-HT4 receptors are associated with cholinergic nerves lining the colon, tegaserod (maleate) stimulates colonic motility and transit in vivo, in both healthy and diseased gastrointestinal tracts.{24430,24429} However, it lacks selectivity, since it also acts as an antagonist for the 5-HT2A, 5-HT2B, and 5-HT2C receptors (Ki = 32, 3.9, and 100 nM, respectively).{24435,24431,24429} It is a weak agonist of 5-HT3 (Ki ≤ 10 μM).{24433}  

 

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Description

A potent agonist of the serotonin 4 receptor (5-HT4, Ki = 3.9-31 nM; also acts as an antagonist for the 5-HT2A, 5-HT2B, and 5-HT2C receptors (Ki = 32, 3.9, and 100 nM, respectively); stimulates colonic motility and transit in vivo

Formal name: 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide, 2Z-butenedioate

Synonyms:  SDZ-HTF 919|Zelnorm

Molecular weight: 417.5

CAS: 189188-57-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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