13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is the primary metabolite of PGE2 (Item No. 14010) in plasma.{182} Endogenous or infused PGE2 is rapidly metabolized by the enzymes 15-hydroxy PGDH and 15-oxo-PG Δ13-reductase to form 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 accumulates to detectable levels; plasma levels in humans are between 10-100 pg/ml.{366,433} It undergoes further metabolism and chemical decomposition, giving it a relatively short half-life. In dogs, the plasma half-life of 13,14-dihydro-15-keto PGE2 is about 9 minutes.{433} In humans the metabolite has a similar short half-life, making it a poor choice of analytes for assays designed to measure total PGE2 biosynthesis.{4383,581}
The primary metabolite of PGE2 in plasma which is formed through the 15-hydroxy PGDH pathway
Formal name: 9,15-dioxo-11α-hydroxy-prost-5Z-en-1-oic acid
Synonyms: 13,14-dihydro-15-keto PGE2
Molecular weight: 352.5
CAS: 363-23-5
Purity: ≥95%
Formulation: A solution in methyl acetate
Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
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