Inhibits glycolysis though the inactivation of mitochondria-bound hexokinase; decreases oxygen consumption as well as aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells (IC50s = 90 and 45 μM

Lonidamine – 5 mg

Brand:
Cayman
CAS:
50264-69-2
Storage:
-20
UN-No:
Non-Hazardous - /

Lonidamine, originally identified as a potent antispermatogenic agent, inhibits glycolysis though the inactivation of mitochondria-bound hexokinase. It can decrease oxygen consumption as well as aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells with IC50 values of 90 and 45 μM, respectively.{23379} A role for lonidamine as a therapeutic for mitochondrial dysfunction has been explored in various disorders, including cancer, neurodegenerative and neuromuscular diseases, obesity, and diabetes.{23378,23377,23376}  

 

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Description

Inhibits glycolysis though the inactivation of mitochondria-bound hexokinase; decreases oxygen consumption as well as aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells (IC50s = 90 and 45 μM, respectively)

Formal name: 1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid

Synonyms:  AF 1890|DICA|Diclondazolic Acid

Molecular weight: 321.2

CAS: 50264-69-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Metabolism||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience

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