A selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity to muscarinic receptors (Ki = 16 nM) and is a positive allosteric modulator of P2X7 receptors; inhibits histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies

Clemastine (fumarate) – 250 mg

Brand:
Cayman
CAS:
14976-57-9
Storage:
-20
UN-No:
Non-Hazardous - /

Clemastine is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM).{23214} It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling.{23212} Clemastine has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.{23213}  

 

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Description

A selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity to muscarinic receptors (Ki = 16 nM) and is a positive allosteric modulator of P2X7 receptors; inhibits histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies

Formal name: ​(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-pyrrolidine, 2E-butenedioate​

Synonyms: 

Molecular weight: 460

CAS: 14976-57-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Neuroscience|Neuroprotection

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