A loop diuretic with good absorption and pharmacodynamic properties; acts as an inhibitor of NKCC1 and the kidney-specific NKCC2 (Ki = 0.5 and 59 μM for human and rabbit NKCC1

Bumetanide – 1 g

Brand:
Cayman
CAS:
28395-03-1
Storage:
-20
UN-No:
Non-Hazardous - /

Bumetanide is a loop diuretic with good absorption and pharmacodynamic properties.{23240,23239} It acts as an inhibitor of the Na-K-Cl cotransporter 1 (NKCC1) and the kidney-specific NKCC2 (Ki = 0.5 and 59 μM for human and rabbit NKCC1, respectively).{23243,23244} Bumetanide also inhibits several isoforms of carbonic anhydrase.{23242}  

 

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Description

A loop diuretic with good absorption and pharmacodynamic properties; acts as an inhibitor of NKCC1 and the kidney-specific NKCC2 (Ki = 0.5 and 59 μM for human and rabbit NKCC1, respectively)

Formal name: 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-benzoic acid

Synonyms:  PF 1593|Ro 10-6338

Molecular weight: 364.4

CAS: 28395-03-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Kidney & Renal Disease

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