A positive allosteric modulator of GluA2; increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC50s = 45.4 and 63.4 nM

CMPDA – 25 mg

Brand:
Cayman
CAS:
380607-77-2
Storage:
-20
UN-No:
Non-Hazardous - /

CMPDA is a positive allosteric modulator of the ionotropic glutamate receptor GluA2.{49253} It increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC50s = 45.4 and 63.4 nM, respectively). CMPDA (10 μM) inhibits desensitization of rat GluA2o and GluA2i receptors, as well as slows the rate of deactivation of GluA2o, but not GluA2i, receptors, in HEK293 cells.  

 

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Description

A positive allosteric modulator of GluA2; increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC50s = 45.4 and 63.4 nM, respectively); inhibits desensitization of rat GluA2o and GluA2i receptors, as well as slows the rate of deactivation of GluA2o, but not GluA2i, receptors, in HEK293 cells at 10 μM,

Formal name: N,N’-(1,4-phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide

Synonyms: 

Molecular weight: 376.5

CAS: 380607-77-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience

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