A natural sesquiterpene alkaloid that inhibits AChE in rat cortex in vitro (IC50 = 82 nM) and displays oral AChE inhibitory activity in animals

(−)-Huperzine A – 10 mg

Brand:
Cayman
CAS:
102518-79-6
Storage:
-20
UN-No:
Excepted Quantity - 1544 / 6.1

(−)-Huperzine A is a natural sesquiterpene alkaloid first isolated from Huperzia, a club moss used in Chinese medicine for its neuroprotective activity.{31509} It inhibits acetylcholinesterase (AChE) in rat cortex in vitro (IC50 = 82 nM) and displays oral AChE inhibitory activity in animals.{31509} (−)-Huperzine A has potential applications in a variety of neuroprotective roles, including protection against organophosphate nerve agents and ameliorating symptoms of Alzheimer’s disease.{31509,31510}  

 

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Description

A natural sesquiterpene alkaloid that inhibits AChE in rat cortex in vitro (IC50 = 82 nM) and displays oral AChE inhibitory activity in animals

Formal name: (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one

Synonyms:  (−)-Selagine|Hup A

Molecular weight: 242.3

CAS: 102518-79-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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