An immediate precursor to cholesterol; accumulates in Smith-Lemli-Opitz syndrome (SLOS); highly susceptible to free radical oxidation

7-dehydro Cholesterol – 50 g

Brand:
Cayman
CAS:
434-16-2
Storage:
-20
UN-No:
Non-Hazardous - /

7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol.{22849} It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features.{22849,27281} It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS.{22849} 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 (Item No. 14611).{22849} 7-DHC is a provitamin that is converted to vitamin D3 (Item No. 11792) by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.{23284,23286}  

 

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Description

An immediate precursor to cholesterol; accumulates in Smith-Lemli-Opitz syndrome (SLOS); highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS; levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944; converted to vitamin D3 by UVB light ex vivo

Formal name: cholesta-5,7-dien-3β-ol

Synonyms:  7-DHC|NSC 18159|Provitamin D3|Δ7-Cholesterol

Molecular weight: 384.6

CAS: 434-16-2

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Natural Products|Vitamins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Vitamin D Receptor||Research Area|Endocrinology & Metabolism|Inborn Errors of Metabolism||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience

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