A DHCR7 inhibitor that prevents cholesterol biosynthesis and Hedgehog signaling; used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome

AY 9944 – 10 mg

Brand:
Cayman
CAS:
366-93-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50 = 13 nM), which interferes with the conversion of 7-dehydro cholesterol (Item No. 14612) to cholesterol.{27278,27282} Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the level of Smoothened or by loss of Suppressor of Fused.{27279} AY 9944 inhibition of DHCR7 has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome, a disorder brought about by mutations in the DHCR7 gene, in animal models.{27282,27280} However, AY 9944 is highly teratogenic, producing congenital defects in offspring when fed to pregnant animals.{27281}  

 

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Description

A DHCR7 inhibitor that prevents cholesterol biosynthesis and Hedgehog signaling; used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome, a disorder brought about by mutations in the DHCR7 gene, in animal models

Formal name: trans-N1,N4-bis[(2-chlorophenyl)methyl]-1,4-cyclohexanedimethanamine, dihydrochloride

Synonyms: 

Molecular weight: 464.3

CAS: 366-93-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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