A potent

WAY-100635 (maleate) – 10 mg

Brand:
Cayman
CAS:
1092679-51-0
Storage:
-20
UN-No:
Non-Hazardous - /

WAY-100635 is a potent, silent antagonist of serotonin 5-HT1A receptors with an IC50 value of 2.2 nM (Ki = 0.8 nM) for inhibiting 5-HT1A receptors in rat hippocampal membranes.{23126,23127} Because it displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes, WAY-100635 is classically used to examine the distribution and function of 5-HT1A receptors.{23128} However, WAY-100635 has also been shown to exhibit agonist activity at dopamine D4 receptors (Kd = 2.4 nM).{23125}  

 

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Description

A potent, silent antagonist of serotonin 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.8 nM) with 100-fold selectivity over other 5-HT subtypes; also exhibits agonist activity at dopamine D4 receptors (Kd = 2.4 nM)

Formal name: N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide, 2Z-butenedioate

Synonyms: 

Molecular weight: 538.6

CAS: 1092679-51-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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