A cell-penetrating peptide inhibitor of calpain (IC50 = 5 nM) which completely abolishes calpain activity in platelets; also a potent inhibitor of cathepsin K (IC50 = 0.11 nM)

Calpeptin – 5 mg

Brand:
Cayman
CAS:
117591-20-5
Storage:
-20
UN-No:
Non-Hazardous - /

Calpeptin is a cell-penetrating peptide inhibitor of calpain (IC50 = 5 nM) which completely abolishes calpain activity in platelets.{23055,23057,23056} In this way, it inhibits both collagen- and thrombin-induced aggregation of platelets.{22713} Calpeptin is also a potent inhibitor of cathepsin K (IC50 = 0.11 nM).{23058}  

 

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Description

A cell-penetrating peptide inhibitor of calpain (IC50 = 5 nM) which completely abolishes calpain activity in platelets; also a potent inhibitor of cathepsin K (IC50 = 0.11 nM)

Formal name: N-[(1S)-1-[[[(1S)-1-formylpentyl]amino]carbonyl]-3-methylbutyl]-carbamic acid, phenylmethyl ester

Synonyms: 

Molecular weight: 362.5

CAS: 117591-20-5

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases

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