A selective inhibitor of STAT3 activation

Stattic – 50 mg

Brand:
Cayman
CAS:
19983-44-9
Storage:
-20
UN-No:
Non-Hazardous - /

Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities.{23053} Stattic is a small molecule inhibitor of STAT3.{23053} It selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC50 = 5.1 μM at 37°C).{23053} At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.{23053}  

 

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Description

A selective inhibitor of STAT3 activation, dimerization and nuclear translocation (IC50 = 5.1 μM at 37°C); 10 μM induces apoptosis in STAT3-dependent breast cancer cells

Formal name: 6-nitro-1,1-dioxide-benzo[b]thiophene

Synonyms:  STAT3 Inhibitor V

Molecular weight: 211.2

CAS: 19983-44-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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