Inhibits PP1 (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) while only weakly inhibiting the activity of PP2B (IC50 = 1 mM); stimulates cell cycle progression and induces premature mitosis and has been shown to be active in various cancer cell lines

Cantharidin – 100 mg

Brand:
Cayman
CAS:
56-25-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Cantharidin is a natural toxin produced by blister beetles that moderately inhibits protein phosphatases 1 (PP1) (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) and only weakly inhibits the activity of PP2B (IC50 = 1 mM).{23052,21678} It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.{21678}  

 

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Description

Inhibits PP1 (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) while only weakly inhibiting the activity of PP2B (IC50 = 1 mM); stimulates cell cycle progression and induces premature mitosis and has been shown to be active in various cancer cell lines

Formal name: (3aR,4S,7R,7aS)-rel-hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione

Synonyms:  NSC 61805

Molecular weight: 196.2

CAS: 56-25-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Toxins||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Cycle

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