A potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM

PF-670462 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
950912-80-8
Storage:
22
UN-No:
Non-Hazardous - /

The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines.{23082,23080} PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively).{23083} It less effectively inhibits a wide variety of related or common kinases.{23083} Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals.{23083,23081} It also blocks the locomotor response to amphetamines in mice.{23080}  

 

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Description

A potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively); less effectively inhibits a wide variety of related or common kinases; disrupts circadian rhythms in cells and animals; blocks the locomotor response to amphetamines in mice

Formal name: 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine, dihydrochloride

Synonyms: 

Molecular weight: 410.3

CAS: 950912-80-8

Purity: ≥99%

Formulation: A pale yellow to yellow solid

Product Type|Biochemicals|Kinase Inhibitors|CK1||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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