A competitive antagonist of the nucleotide receptor P2X7 (pIC50 = 6.9); inhibits both calcium flux and IL-1β release mediated by P2X7 while not affecting the activity of other P2X receptors; used to evaluate the role of P2X7 in nociception

A-438079 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
899431-18-6
Storage:
22
UN-No:
- 2811 / 6.1

A-438079 is a competitive antagonist of the nucleotide receptor P2X7 (pIC50 = 6.9).{22914} It inhibits both calcium flux and IL-1β release mediated by P2X7 while not affecting the activity of other P2X receptors.{22914,22913} A-438079 is effective in evaluating the role of P2X7 in nociception, oxidative stress, and apoptosis in cells and animals.{22915,22916,22917}  

 

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Description

A competitive antagonist of the nucleotide receptor P2X7 (pIC50 = 6.9); inhibits both calcium flux and IL-1β release mediated by P2X7 while not affecting the activity of other P2X receptors; used to evaluate the role of P2X7 in nociception, oxidative stress, and apoptosis in cells and animals

Formal name: 3-[[5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl]methyl]-pyridine, monohydrochloride

Synonyms: 

Molecular weight: 342.6

CAS: 899431-18-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Neuroscience|Pain Research

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