A selective Group III metabotropic glutamate receptor agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM); depresses synaptic transmission in glutamatergic pathways in the hippocampus

L-AP4 – 10 mg

Brand:
Cayman
CAS:
23052-81-5
Storage:
-20
UN-No:
Non-Hazardous - /

Metabotropic glutamate receptors (mGluR) function to modulate excitatory synaptic transmission in the brain. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. L-AP4, an analog of L-glutamic acid, is a selective Group III mGluR agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM).{22831,22827,21634} L-AP4 has been shown to depress synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina as well as act as an agonist at the quisqualate-sensitized AP6 site in hippocampus.{22831}  

 

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Description

A selective Group III metabotropic glutamate receptor agonist that functions presynaptically to suppress glutamate release (IC50 = 2.5 μM); depresses synaptic transmission in glutamatergic pathways in the hippocampus, olfactory bulb, and retina

Formal name: 2S-amino-4-phosphono-butanoic acid

Synonyms:  L-(+)-2-amino-4-phosphorobutanoic acid|L-APB

Molecular weight: 183.1

CAS: 23052-81-5

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience

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