A potent

Apafant – 5 mg

Brand:
Cayman
CAS:
105219-56-5
Storage:
-20
UN-No:
Non-Hazardous - /

Platelet-activating factor (PAF) is a biologically active phospholipid that activates platelets, polymorphonuclear leukocytes, monocytes, and macrophages.{939} PAF also increases vascular permeability, decreases cardiac output, induces hypotension, stimulates uterine contraction, and has been implicated in pathological processes, such as inflammation and allergy.{11753} Apafant is a water soluble, selective PAF receptor antagonist that inhibits PAF binding to human PAF receptors with a Ki value of 9.9 nM.{22980} Apafant displays anti-inflammatory, antiangiogenic, and anticancer activity.{22981,22980,16870}  

 

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Description

A potent, selective PAF receptor antagonist (Ki = 9.9 nM at human PAF receptors); displays anti-inflammatory, antiangiogenic, and anticancer activity

Formal name: 3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone

Synonyms:  WEB 2086

Molecular weight: 456

CAS: 105219-56-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Immunology & Inflammation

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