A less potent

LY2183240 2’-isomer – 10 mg

Brand:
Cayman
CAS:
1010096-65-7
Storage:
-20
UN-No:
Non-Hazardous - /

LY2183240 (Item No. 10008663) is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis.{14134,15431,16339} It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain.{14134} LY2183240 2’-isomer is a less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively.{15431}  

 

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Description

A less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively

Formal name: 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide

Synonyms: 

Molecular weight: 307.4

CAS: 1010096-65-7

Purity: ≥98%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Pain Research

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