A muscarinic acetylcholine receptor agonist; binds to human hippocampal

(+)-Pilocarpine (hydrochloride) – 10 g

Brand:
Cayman
CAS:
54-71-7
Storage:
-20
UN-No:
Excepted Quantity - 1544 / 6.1

(+)-Pilocarpine is a muscarinic acetylcholine receptor agonist that binds to human hippocampal, pons, and submandibular gland membranes, which are endogenously enriched in the M1, M2, and M3 receptor subtypes, respectively (Kiapps = 6, 8.2, and 6.9 μM, respectively).{48747} It induces salivary secretion in rats when administered intraperitoneally at a dose of 1 mg/kg.{48748} Topical administration of (+)-pilocarpine inhibits methylcellulose-induced increases in intraocular pressure in rabbits in a dose-dependent manner.{48749} (+)-Pilocarpine is a chemoconvulsant that has been used in the generation of temporal lobe epilepsy animal models.{52179,26629,23165} Formulations containing (+)-pilocarpine have been used in the treatment of elevated intraocular pressure and dry mouth.  

 

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Description

A muscarinic acetylcholine receptor agonist; binds to human hippocampal, pons, and submandibular gland membranes, which are endogenously enriched in the M1, M2, and M3 receptor subtypes, respectively (Kiapps = 6, 8.2, and 6.9 μM, respectively); induces salivary secretion in rats at 1 mg/kg; topical administration inhibits methylcellulose-induced increases in intraocular pressure in rabbits in a dose-dependent manner; a chemoconvulsant that has been used in the generation of temporal lobe epilepsy animal models

Formal name: (3S,4R)-3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone, monohydrochloride

Synonyms:  NSC 5746

Molecular weight: 244.7

CAS: 54-71-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Ophthalmology||Research Area|Neuroscience|Seizure Disorders

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