A reversible and selective inhibitor of calpain I (μ-calpain

Calpain Inhibitor XII – 1 mg

Brand:
Cayman
CAS:
181769-57-3
Storage:
-20
UN-No:
Non-Hazardous - /

Calpain inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki = 19 nM), with lower affinities for calpain II (m-calpain, Ki = 120 nM) and cathepsin B (Ki = 750 nM).{23178} Calpain inhibitors, including this compound, have been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.{23174,23175,23177,23179}  

 

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Description

A reversible and selective inhibitor of calpain I (μ-calpain, Ki = 19 nM), with lower affinities for calpain II (m-calpain, Ki = 120 nM) and cathepsin B (Ki = 750 nM)

Formal name: [3-methyl-1-[[[1-[oxo[(2-pyridinylmethyl)amino]acetyl]butyl]amino]carbonyl]butyl]-carbamic acid, phenylmethyl ester

Synonyms:  Z-L-Nva-CONH-CH2-2-Py

Molecular weight: 482.6

CAS: 181769-57-3

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Heart||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience

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