An irreversible inhibitor of TPPII commonly used at 10-100 µM; does not significantly interfere with the chymotrypsin-like activity of the proteasome; also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM

AAF-CMK (trifluoroacetate salt) – 10 mg

Brand:
Cayman
CAS:
184901-82-4
Storage:
-20
UN-No:
Non-Hazardous - /

Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides.{22987} AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 µM.{22991,22989,22990} It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM.{22988}  

 

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Description

An irreversible inhibitor of TPPII commonly used at 10-100 µM; does not significantly interfere with the chymotrypsin-like activity of the proteasome; also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 µM

Formal name: L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-L-alaninamide, mono(trifluoroacetate)

Synonyms:  N-Ala-Ala-Phe-CMK|Tripeptidyl Peptidase Inhibitor II

Molecular weight: 453.8

CAS: 184901-82-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis

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